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The major application of PTFE, consuming about 50% of production, is for the insulation of wiring in aerospace and computer applications (e.g. hookup wire, coaxial cables). This application exploits the fact that PTFE has excellent dielectric properties, especially at high radio frequencies making it suitable for use as an excellent insulator in connector assemblies and cables, and in printed circuit boards used at microwave frequencies. Combined with its high melting temperature, this makes it the material of choice as a high-performance substitute for the weaker and lower-melting-point polyethylene commonly used in low-cost applications.

In industrial applications, owing to its low friction, PTFE is used for plain bearings, gears, slide plates, seals, gaskets, bushings, and more applications with sliding action of parts, where it outperforms acetal and nylon.

Its extremely high bulk resistivity makes it an ideal material for fabricating long-life electrets, the electrostatic analogs of permanent magnet 

PTFE film is also widely used in the production of carbon fiber composites as well as fiberglass composites, notably in the aerospace industry. PTFE film is used as a barrier between the carbon or fiberglass part being built, and breather and bagging materials used to incapsulate the bondment when debulking (vacuum removal of air from between layers of laid-up plies of material) and when curing the composite, usually in an autoclave.

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